Preprints

Created 24 Sep 2026

Host membrane cholesterol constrains constitutive signaling of the oncogenic KSHV GPCR ORF74

by Park, J. B., Sahoo, A. R., Ryu, A., Buck, M., Jung, J.

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Created 17 Sep 2026

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

by Khan, J., Mehmood, S., Al Abir, F., Wei, M., Muzaffar, S., Mohiuddin, S., Liu, S., Waseem, M., Akhter, J., Liu, Z., Crossman, D. K., Kamata, M., Chen, J. Y., Raman, C., Elmets, C., Zhang, S., Athar, M., Jin, L.

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Created 09 Sep 2026

Synonymous HTT CAA/CCA-loss variants associated with early Huntington disease onset enhance toxicity beyond somatic instability

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Created 11 Sep 2026

FANCM restrains structural genome evolution and defines a synthetic lethal dependency in BRCA1-deficient breast cancer

by Panday, A., Ramadan, F., Shah, S. B., Subedi, U., Stephens, Z. D., Venkatachalam, A., Yadav, N., Pandit, V., Dubey, S., Latka, S., Villanueva, H., Kaufmann, S. H.

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Created 18 Sep 2026

Integrating complementary biological information for multi-objective enzyme engineering

by Blalock, N., Sosa, Y., Heuschkel, J., Li, R., Ma, X., Radomkit, S., Wu, H., Buono, F., Song, J., Pefaur, N., Kingsley, L. J., Romero, P. A.

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Created 03 Oct 2026

Balancing receptor engagement and payload catalytic activity broadens the therapeutic window of immunotoxins

by Liang, H., Beilhartz, G. L., Wang, X., Zou, K., Cao, S. B., Melnyk, R. A.

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Created 14 Sep 2026

Targeted dephosphorylation of Tau at the endogenous level promotes its association with microtubules.

by Sathe, G., Berterame, F., Cartwright, T., Spallek, R., Zhao, J.-F., Bagale, A. R., Gourlay, R., Wood, N. T., Macartney, T. J., Sapkota, G. P.

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Created 11 Sep 2026

Self-Architecting Protein Transformers: An Empirical Study

by Cirrincione, G., Ficarra, E., Lovino, M.

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Created 21 Sep 2026

BRIDGE-AD reveals Alzheimer's disease effectors through interpretable large-scale omics integration

by Cerneckis, J., Baltusyte, G., Convey, H., Sun, G., Abela, Z. C. E., Ramirez, M., Wang, D., Sun, G., Zhou, T., Spring, D., Saeb-Parsy, K., Han, N., Shi, Y.

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Created 08 Sep 2026

A beneficial bacteria influences myo-inositol homeostasis to protect plants during drought

by Tran, T., Santiago-Morales, K. D., Knoor, L. H., Kelley, B. R., O'Banion, B., Lebeis, S. L.

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