Latest Research Preprints - Life Science Network

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This list contains preprints from the last 30 days only. Use the search function to access older preprints.

The default sorting of preprints in this list is by the date when the preprint was uploaded or imported to our database (shown on top). Publication date is indicated below the title.

Created 22 Sep 2026

The DNA Legacy of Thomas Jefferson

by Green, R. E., Vohr, S. H., Kapp, J. D., Ailes, J. E., Sacco, S., Nguyen, R., Cahill, J., Heintzman, P. D., Flores, J., Kistler, L., Hofman, C. A., Fleischer, R. C., Shapiro, B., Kurin, R.
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Created 23 Sep 2026

De novo design of protease-activatable cytokine prodrugs

by Shin, H., Tello, J. G., Kim, C. J., Chun, J.-H., Peprah, F., Parent, B. D., Atajanova, T., Mahmud, R. A. I., Qiang, L., Aguirre, A. J., Dougan, S. K., Dougan, M., Baker, D.
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Created 14 Sep 2026

The Separable Organization of Immune Transcriptional Responses

by Zahid, H. J.
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Created 18 Sep 2026

Integrating structural and biological evidence to rerank ESMFold2 protein-protein interactions

by Xie, J., Li, M., Chai, Y., Ou, G., Li, W., Guo, Z.
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Created 11 Sep 2026

Specificity-driven protein binder design with Odin-Multi

by Brasas, V., Christensen, C. R., Björnsson, K. H., Moller, V. E., Scapolo, B., Benard-Valle, M., Nygaard, M. M., Nielsen, J. C., Hadrup, S. R., Johansen, K. H., Jenkins, T. P.
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Created 13 Sep 2026

Interaction Profiles as a Universal Language for Generative Molecular Design with ShEPhERD-2

by Abeywardane, K. A., Walker, K., Coley, C. W.
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Created 31 Aug 2026

FlexiTAC enables controllable PROTAC linker generation across diverse structural settings using a Bayesian flow network with posterior guidance

by Li, Y., Zhao, Y., Zhou, L., Huang, C., Xu, Q., Chen, Y., Qin, Z., Fan, K., Yang, J., Cao, D.
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Created 21 Sep 2026

A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease

by Lin, D., Atkinson, J. R., Wu, W., Chen, M., Jayasekara, S., Segal, B. M., Ma, A., Gao, J.
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Created 15 Sep 2026

Cell type-specific histone acetylation landscape in Alzheimer's disease reveals a putative role of MITF in microglia
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Created 08 Sep 2026

Inverse FoldDir: Structure-conditioned Protein Sequence Design by Dirichlet Flow Matching

by TARTICI, A., Stojkovic, M., Tian, A., Jewett, M. C., Altman, R. B., Wittmann, B. J.
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