Preprints

Created 14 Sep 2026

Lipid nanoparticle induced model endosomal membrane disruption

by Pramanik, S., Vasudevan, A., Liang, Z., Karole, A., Berchel, M., Jaffres, P.-A., Eygeris, Y., Sahay, G.

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Created 21 Sep 2026

A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease

by Lin, D., Atkinson, J. R., Wu, W., Chen, M., Jayasekara, S., Segal, B. M., Ma, A., Gao, J.

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Created 08 Sep 2026

Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences

by Pangilinan, G. R., Patil, S., Mires, F., Ye, G., Bogomilova, V., Tilley, L., Goldkorn, T., McGill, C. J., Ballou, N., Li, X., Jadhav, U., Benayoun, B. A., Shwartz, Y.

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Created 22 Sep 2026

The DNA Legacy of Thomas Jefferson

by Green, R. E., Vohr, S. H., Kapp, J. D., Ailes, J. E., Sacco, S., Nguyen, R., Cahill, J., Heintzman, P. D., Flores, J., Kistler, L., Hofman, C. A., Fleischer, R. C., Shapiro, B., Kurin, R.

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Created 16 Sep 2026

Targeting IL-2 to inflamed tissues via oxidation-specific epitopes enables third-generation bispecific IL-2 therapeutics

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Created 12 Sep 2026

Large-Vessel Venous Signal Confounds Apparent Amygdala Activation in BOLD fMRI

by Diamandis, Z., Tyszka, J. M., Adolphs, R.

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Created 16 Sep 2026

Multistate Enzyme Design Enables Efficient and Stereoselective Multistep Catalysis

by Pham, N. T. H., Guo, R., Garcia Jimenez, R. P., Hutton, A. E., Johannissen, L. O., Wehrstedt, J. A., Seifinoferest, B., Birch-Price, Z., Berreur, J., Hay, S., Thompson, M. C., Green, A. P., Chica, R. A.

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Created 18 Sep 2026

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

by Yan, N. L., Mayer, M., Melo, A. A., Ayers, J. I., Mordes, D. A., Seeley, W. W., Prusiner, S. B., Tse, E., Chittoor-Vinod, V. G., Merz, G. E.

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Created 14 Sep 2026

Nanoscale chemical tomography reveals organic and inorganic clusters in fossilised dinosaur tooth

by Hsu, Y., Schwarz, T., Triccas, A., Kostka, A., Chen, X., Jang, K., Scheu, C., Razker, B., Tuetken, T., Gault, B., Dumont, M.

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Created 15 Sep 2026

Oxidized phosphatidylinositol impairs lysosomal membrane repair to promote ferroptosis

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