Latest Research Publications - Life Science Network

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Created 14 Jul 2026

AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells.

by Anis Messaoudi, Marie Garcia, Marc Audebert, Julien Vignard, Gladys Mirey — Archives of toxicology. Jul 14, 2026.
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Created 14 Jul 2026

Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes.

by Ahmed S M Ali, Heike Sprenger, Albert Braeuning, Jens Kurreck — Archives of toxicology. Jul 14, 2026.
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Created 14 Jul 2026

Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.

by Ellen Mayara Souza Cruz, Virginia Márcia Concato-Lopes, Mariana Barbosa Detoni, Manoela Daiele Gonçalves-Lens, Milena Cremer de Souza, Fabrício Seidy Ribeiro Inoue, Angélica Paulina Nunes, Elaine da Silva Siqueira, Ana Carolina Jacob Rodrigues, Yasmin Munhoz Dos Santos-Destro, Natália Concimo Santos, João Manoel de Sousa Silva, Éder Ignácio da Silva, Maiara Voltarelli Providello, Danielle Lazarin-Bidóia, Fábio Rodrigues Ferreira Seiva, Wander Rogério Pavanelli — Archives of toxicology. Jul 14, 2026.
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Created 14 Jul 2026

Comprehensive analysis of neutrophil extracellular traps-associated inflammatory genes for patients with idiopathic pulmonary fibrosis.

by Changhui Lang, Jieling Wu, Nuoxin Wang — Molecular genetics and genomics : MGG. Volume 301(1). Jul 14, 2026.
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Created 14 Jul 2026

Development of new coumarin-piperazine-N-phenylacetamid derivatives as potent tyrosinase inhibitors: In vitro and in silico evaluations.

by Mohammad Mahdi Aghanour Ashtiani, Somaye Karimian, Aida Iraji, Navid Dastyafteh, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mohammad Mahdavi, Peyman Salehi — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1105-1118. Epub Apr 29, 2026.
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Created 14 Jul 2026

Piperazine derivatives as anticancer agents: a medicinal chemistry review of structure, mechanism, and clinical translation.

by Trapti Porwal, Rajnish Kumar, Shristi Tripathi, Salahuddin — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1031-1063. Epub May 15, 2026.
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Created 14 Jul 2026

Discovery of new bioactive secondary metabolites from the stem bark of oroxylum indicum: isolation, structural identification, antimicrobial and cytotoxicity assessment.

by Dixhya Rani, Meenakshi Sharma, Urvashi Dhiman, Tashi Palmo, Ashutosh Shahi, Kuljit Singh, Prasoon Gupta — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1161-1185. Epub May 18, 2026.
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Created 14 Jul 2026

Design, synthesis, and activity study of heterocyclic derivatives as JAK inhibitors.

by Shukhrat Gaybullaev, MiaoMiao Shi, Deng Zang, Shan Yang, Jiale Yan, Sardor Shakarov, Yuldash Takhirov, Davron Turgunov, Liyin Jiang, Jiangyu Zhao, Khurshed Bozorov, Chao Niu — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1141-1160. Epub May 26, 2026.
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Created 14 Jul 2026

Design, Synthesis and Antitumor Activity Evaluation in Vitro of Novel 1,6-Naphthyridine Derivatives.

by Xiao-Jie Si, Xin-Yi Ma, Su-Lin Zhang, Ming-Yue Zheng, Motahareh Asgari, Chen-Guo Feng — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1186-1200. Epub May 28, 2026.
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Created 14 Jul 2026

Exploring new quinoxaline, quinoline, and naphthalene carboxamides as HDAC-targeted anticancer agents: Cytotoxicity, enzymatic HDAC evaluation, and in silico studies.

by Jariya Jampahom, Jiratthakan Prathumchat, Siripit Pitchuanchom, Chadaporn Leerat, Narissara Namwan, Thanaset Senawong, Jantana Yahuafai, Kwanjai Kanokmedhakul, Chanokbhorn Phaosiri, Mongkol Nontakitticharoen — Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. Volume 35(6): 1201-1221. Epub May 28, 2026.
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