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Created 12 Nov 2026

Approaching Machine Learning for Length of Stay Prediction in Sepsis Patients Presenting to the Emergency Department From 2014 to 2024.

by Zaira Rehman, Saima Ali, Ghazanfar Saleem, Irsa Nadeem, Ammad Fahim — Shock (Augusta, Ga.). Volume 66(6): 1221-1233. Dec 01, 2026.
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Created 12 Nov 2026

Outcomes of Cardiogenic Shock Secondary to Decompensated Heart Failure Versus Acute Myocardial Infarction.

by Hritvik Jain, Nandan Patel, Jyoti Jain, Aman Goyal, Siddharth P Agrawal, Ran Lee, Andrew R Higgins, Alexander G Truesdell, J Dawn Abbott, Saraschandra Vallabhajosyula — Shock (Augusta, Ga.). Volume 66(6): 1262-1265. Dec 01, 2026.
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Created 12 Nov 2026

ENPP1 deficiency in siblings with apparently discordant phenotypes: case report and a review of the literature.

by Tamaki Wada, Yuki Miyahara, Yuiko Hasegawa, Katsuya Hirata, Keiko Matsuoka, Yoichiro Ishii, Narutaka Mochizuki, Nobuhiko Okamoto, Yuri Etani, Masanobu Kawai — Journal of pediatric endocrinology & metabolism : JPEM. Nov 13, 2026.
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Created 12 Nov 2026

Translational Application of the Five-Star Matrix for the Structure-Guided Optimization of a Bicyclopiperazine DEL Hit into Bcpz 1.5: A Potent Monoacylglycerol Lipase Inhibitor with Functional Inhibition in Human Brain Homogenate and Efficacy in Neuroinflammatory Models.

by Benjamin Brennecke, Louise Plais, Benoit Hornsperger, Martin Binder, Christian Bartelmus, Markus Bürkler, Fionn O'Hara, Carsten Kroll, Satoshi Tsuchiya, Buelent Kocer, Hans Richter, Martin Ritter, Katrin Groebke Zbinden, Maude Giroud, Manfred Schneider, Andrea Martella, Ann Petersen, Wiebke Saal, Melanie Guerard, Axel Pähler, Luca Gobbi, Antonia F Stepan, Moreno Wichert, Andreas Topp, Dominik Heer, Iris Ruf, Remo Hochstrasser, Manuel Hilbert, Sylwia Huber, Anto Pavlovic, Juliane Stephanus, Sina Simon, Achi Haider, Mario van der Stelt, Matthias Beat Wittwer, Ludovic Collin, Jörg Benz, Bernd Kuhn, Uwe Grether — Journal of medicinal chemistry. Volume 69(21): 25832-25854. Nov 12, 2026.
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Created 12 Nov 2026

Lipid Droplet-Targeted Near-Infrared II Type I AIE Photosensitizer Promotes Ferroptosis by Activating Lipophagy.

by Dongxiu Li, Yue Jin, Jiabao Zhuang, Jiawen Chen, Yuhe Zhou, Xue Zhao, Na Zhao, Nan Li — Journal of medicinal chemistry. Volume 69(21): 25791-25806. Nov 12, 2026.
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Created 12 Nov 2026

Structure-Guided Discovery of Orally Bioavailable Allosteric SLC6A19 Inhibitors that Promote Urinary Amino Acid Excretion In Vivo.

by Tao Wang, Matthew S Dowling, Dahui Zhou, David Jonathan Wasilko, Meihua Tu, Denis Feliers, Barbara Bernardo, Joseph Tillotson, Wenzhe Ma, Janice Brown, Zachary Johnson, Joshua A Lees, Andrew Fensome, Andre Shavnya, Jennifer Clemens, Steven Coffey, Caroline A Blakemore, Melissa Avery, Jamison B Tuttle, Phillip Hudson, Magdalena Korczynska, John Murray, Jade Williams, Jun Xiao, Jason Dutra, Dianne Hernandez, Kevin D Hesp, Vincent Mascitti, Srinath Jagarlapudi, Rose Keenan, Jessica Ward, Robert Barnes, Emily Jordan, Natalie Ochocki, Daniel Callahan, Kimberly Steen, Amit S Kalgutkar, Kari R Fonseca, Raman Sharma, Nicholas Ferguson, Amanda King-Ahmad, Andrew J Bessire, Amy Moody, Tristan S Maurer, Ingrid A Stock, Ruth Sommese, Tracy Phillips, Paula M Loria, Huixian Wu, David Hepworth, Matthew F Sammons, Lei Zhang, Yuan Zhang — Journal of medicinal chemistry. Volume 69(21): 26102-26115. Nov 12, 2026.
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Created 12 Nov 2026

HER2-Targeting Affibody Equipped with Albumin-Binding Small Molecules for Radiotheranostics.

by Weichen Wang, Ao Shen, Mingxing Huang, Rang Wang, Wei Chen, Guangming Shen, Yaguang Wang, Junshan Geng, Zhao Chen, Dawen Niu, Rong Tian, Yingwei Wang — Journal of medicinal chemistry. Volume 69(21): 26287-26301. Nov 12, 2026.
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Created 12 Nov 2026

FAP-Triggered In Situ Self-Assembly of HPQ in Tumors Empowers 131I Internal Radiotherapy.

by Jiang Wu, Yan Hu, Guoqiang Zhou, Benqin Xu, Chenhao Liao, Yumin Chen, Peixin Lin, Panpan Chen, Tingyou Li, Feng Wang — Journal of medicinal chemistry. Volume 69(21): 26508-26527. Nov 12, 2026.
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Created 12 Nov 2026

The Phenotypic Hit-to-Probe Challenge.

by Sven Herschel, Thomas Ullrich, Enrico Schmidt, Jean Quancard, Dennis Schade — Journal of medicinal chemistry. Volume 69(21): 24996-25011. Nov 12, 2026.
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Created 12 Nov 2026

Ligand-Dependent Affinity but State-Dominated Efficacy in Structure-Based GPCR Pharmacology Prediction.

by Jianxiang Huang, Xin Qiao, Chunhao Zhu, Xiaobing Lan, Shaoyong Lu — Journal of medicinal chemistry. Volume 69(21): 26595-26611. Nov 12, 2026.
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