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Created 12 Nov 2026

Alpha-Lipoic Acid Derivatives: A Multifunctional Neuroprotective Agent with Potential for Treating Ischemic Stroke.

by Jialun Zou, Feng Gao, Yilin Luo, Xinyue Bai, Yuan Ru, Wanyi Cen, Mengdi Lv, Jia Wang, Ning Zhang, Qianqian Hu, Xiaolong Liu — Journal of medicinal chemistry. Volume 69(21): 25181-25202. Nov 12, 2026.
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Created 12 Nov 2026

Development of Long-Acting Teriparatide Analogues through Iterative Peptide Scanning and Site-Specific Modification by Serine/Threonine Ligation.

by Biyao Liu, Kaixuan Song, Hongli Sui, Zhuang Li, Huarong Shao, Fei Liu, Kang Jin — Journal of medicinal chemistry. Volume 69(21): 25957-25970. Nov 12, 2026.
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Created 12 Nov 2026

Design, Synthesis and Dual-Stage Antimalarial Evaluation of β-Carboline-Metronidazole Hybrids: Structure-Activity Relationship and Molecular Docking Correlations.

by Alka Raj Pandey, Suriya Pratap Singh, Rohini Nandi, Shabeer Ali H, Rama Krishna Rayiti, Shovan Ghosh, Gokul Krishnan Nagendran, Sathish Kumar Mudedla, Rabi Sankar Bhatta, Satish Mishra, Koneni V Sashidhara — Journal of medicinal chemistry. Volume 69(21): 26248-26269. Nov 12, 2026.
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Created 12 Nov 2026

Design, Synthesis, and Biological Evaluation of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Psoriasis.

by Ruilin Liu, Yinyan Xiao, Mingyue Xue, Qian Liu, Weijie Hu, Jing Shen, Mingyang Hou, Chunquan Sheng, Yahui Huang — Journal of medicinal chemistry. Volume 69(21): 26336-26353. Nov 12, 2026.
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Created 12 Nov 2026

Influence of Fluorine Substitution Pattern in Arylboronic Acid Caps on the Myocardial Perfusion Imaging Properties of Technetium Monocapped Tris(dioxime) Complexes.

by Ding Ding, Wanjie Ren, Yufan Gu, Min Ju, Yue Zhou, Shuyang Song, Ke Wang, Zongyao Zhang, Lei Wang, Wei Fang — Journal of medicinal chemistry. Volume 69(21): 26078-26088. Nov 12, 2026.
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Created 12 Nov 2026

Design and Biological Evaluation of FAP-Man, a Mannosylated FAP-Targeted Radioglycopeptide for Tumor Imaging and Radionuclide Therapy.

by Miaomiao Song, Entao Liu, Rui Cao, Luming Sun, Peng Wang, Shuang Duan, Ji Tao, Long Qiu, Jin Du, Ning Liu, Feize Li, Chunrong Qu, Lei Jiang, Zhen Cheng — Journal of medicinal chemistry. Volume 69(21): 26425-26435. Nov 12, 2026.
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Created 12 Nov 2026

Lung-Tailored Pyrrolo-pyrimidine DDR Inhibitors Designed for Optimized Local Delivery.

by Roberta Mazzucato, Nicoló Iotti, Eleonora Ghidini, Andrea Rizzi, Fabio Rancati, Serena Bertolini, Fabio Bignami, Alessandro Fioni, Valentina Mileo, Fabio Vaccaro, Allisson Freire Bento, Annalisa Murgo, Anna Maria Capelli, Benjamin Paul Whittaker, Charlotte Matthews, Elizabeth Hann, Daniel Todd, Veronica Marinoni, Laura Carzaniga — Journal of medicinal chemistry. Volume 69(21): 25128-25150. Nov 12, 2026.
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Created 12 Nov 2026

Design, Synthesis, and Antifibrotic Evaluation of Silicon-Incorporated Alkyl Hydrazide Analogs of Tubastatin A: HDAC3 Selective Inhibitor for Ameliorating Liver Fibrosis.

by Laxman D Nandawadekar, Nidhi Sharma, Suriya Panneerselvam, Eagala Ramesh, Rohan R Patekar, Ganesh Routholla, Sandip B Bharate, Sai Balaji Andugulapati, D Srinivasa Reddy — Journal of medicinal chemistry. Volume 69(21): 25549-25574. Nov 12, 2026.
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Created 12 Nov 2026

Chemical Determinants of Spinal Analgesia in NTS2-Selective Macrocycles.

by Michael Desgagné, Nathan Meneboo, Magali Chartier, Malihe Hassanzadeh, Mathieu Choquette, Jean-Michel Longpré, Alexandre Murza, Pierre-Luc Boudreault, Philippe Sarret — Journal of medicinal chemistry. Volume 69(21): 25677-25692. Nov 12, 2026.
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Created 12 Nov 2026

Democratizing Drug Discovery: A Scalable Open-Source Pipeline for Massive Specific Protein Target QSAR Modeling Using ChEMBL.

by Andrea Zaliani, Arianna Pisati, Agnese Pozzi, Alessandro Pedretti, Giulio Vistoli — Journal of medicinal chemistry. Volume 69(21): 25228-25235. Nov 12, 2026.
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