Preprints

Created 13 Aug 2026

STR-PG: A Topology-decoupled Pangenome Framework for Scalable Short-read Genotyping of Short Tandem Repeats

by YUAN, J., XUE, Z., TANG, H., LIU, Y., WANG, J.

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Created 05 Aug 2026

Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma

by SAPRA, L., Bhardwaj, A., Paladhi, A., Farhat, A., Kaur, T., Kaur, S. P., Saini, C., Kumar, V. S., Khan, S. A., Srivastava, R. K.

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Created 08 Aug 2026

ClinOracle: Hierarchical AI Prediction of Target Binding and Patient-Derived Functional Activity Across Diverse Therapeutic Targets

by Abdel-Rahman, S., Gabr, M.

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Created 01 Aug 2026

Real-time electrochemical protein monitoring using molecular pendulum sensors

by Juska, V. B., Chen, Z., Qazi, R., Li, L., Kim, S., Esmaeili, F., Buchsbaum, W., Nashner, A., Donnelly, J., Ayala-Cardona, L. F., Neff, R., Sedlack, A. J. H., Cabezas, M. D., Das, J., Kelley, S. O., Zargartalebi, H.

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Created 29 Jul 2026

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

by Herdy, J. R., Taylor, E. E., Karbacher, L., Borgogno, O., Traxler, L., Lagerwall, J., Huynh, V. A., Lefterova, Z. V., Kang, A., Tosat-Bitrian, C., Kelsey, M. M. G., Sedivy, J., Sinha, S., Gan, L., Bennett, C. F., Reid, D., Mertens, J., Gage, F. H.

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Created 06 Aug 2026

In vitro and in silico characterization of competitive inhibition and repression of DUX4 target gene activation as a therapeutic approach for facioscapulohumeral muscular dystrophy (FSHD)

by Hoffmann, H. M., Finkelstein, A., Geremew, A., Xu, K., Chiprez Meza, V., Mohanty, A., Velasquez, M. F., Liu, M., Engel, A., Kyriakakis, P.

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Created 08 Aug 2026

tinyRNA-seq: An optimized approach to sequencing tiny RNAs and primitive RNA genomes

by Colville, B. W. F., Zhao, J., Hade, L., Szostak, J. W.

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Created 12 Aug 2026

Environmental drivers of heritable trait variation and lag of adaptation to climate in Hordeum murinum

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Created 10 Aug 2026

Extraction of directional electron-density features from diffraction data using spherical-harmonic decomposition

by Panjikar, S., Weiss, M., Jayatilaka, D.

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Created 07 Aug 2026

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

by Varesi, A., Dong, S., Gaddoni, C., Kaufmann, K. B., Wong, T., Merelli, I., Zeng, A. G. X., McLeod, J., Jin, L., di Biasio, I., Novitzky-Basso, I., Mattson, J., Xie, S. Z., Li, B., Ferrari, S., Dick, J. E.

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