Preprints

Created 13 Sep 2026

spAlignDE unifies cross-sample and cross-modal spatial alignment with mismatch-aware differential expression

by Xu, S., Wang, Y., Meng, L., Dalal, A., Yin, Y., Song, D.

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Created 02 Oct 2026

Multi-omics fine-mapping uncovers a pleiotropic intestinal enhancer variant linking PMAIP1 regulation to pig growth and fatness

by Yang, H., Hu, M., Xu, Y., Zhang, J., Zhang, Y., Gou, Y., Du, X., Wang, H., Li, X., Zhao, Y., Xiang, T.

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Created 16 Sep 2026

Targeting IL-2 to inflamed tissues via oxidation-specific epitopes enables third-generation bispecific IL-2 therapeutics

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Created 15 Sep 2026

LIGER2: Scalable Single-Cell Integration with On-Disk Datasets

by Wang, Y., Robbins, A., Gadhvi, G., Welch, J. D.

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Created 14 Sep 2026

Molecular Editing in Protein Degradation: From a Dual NSD2/GSPT1 Degrader to an NSD2-Selective PROTAC and a GSPT1-Selective Molecular Glue

by Shen, W., Liu, Y., Liu, L., Liu, Y., Zhang, Y., Chen, Y., Zhou, Z., Zhang, A., Shen, H., Zhou, F., Huang, W., Ren, X., Parolia, A., Xu, Y., Zhou, Y., Wang, Z., Chinnaiyan, A. M., Ding, K.

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Created 06 Oct 2026

Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA-TCR analysis

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Created 26 Sep 2026

Performance of Rilpivirine-Based Hydrophobic Tags and PROTACs Directed Against HIV-1 Reverse Transcriptase

by Amanor, F. K., Clements, G. D., Khurshid, R., Howard, A. F., Soto-Martinez, D. M., Barkley, C., Yang, Z., Gyawali, K., Kappes, J. C., Reynolds, R. C., Schürer, S. C., Snowden, T. S., Ochsenbauer, C.

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Created 03 Oct 2026

Remembering touch: Somatosensory cortex supports long-term memory for dynamic vibrotactile patterns.

by Schmidt, M. E., Schmidt, T. T., Nierhaus, T., Blankenburg, F.

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Created 23 Sep 2026

Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor

by Chandrasekaran, V., Gupta, R., Angani, M. T., Haddad, T. F. M., Tate, C. G., Ramakrishnan, V., Hinnebusch, A. G.

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Created 02 Oct 2026

Organoid-to-organoid transplantation and pro-neurogenic treatment promote graft integration and neuronal repair in a human ischemic model

by Gomez-Oliva, R., Helgueta, S., Alonso-Galeron, N., Cambier, A., Ghanavatinejad, F., Masset, G., Collin, L., Nunez-Abades, P., Hernandez-Galan, R., Castro, C., Espuny Camacho, I.

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